Molecular Biosciences Research – RIC

Vision

To promote Manav Rachna International Institute of Research and Studies (formerly MRIU) amongst World’s top Research Institutes through excellence in scientific research.

Mission

  • To generate new knowledge by engaging in cutting-edge research.
  • To identify areas of specialization upon which the institute can concentrate relevant to the needs of India and world.
  • To undertake collaborative projects which offer opportunities for engaging academia and industry on a sustainable basis.
  • To develop research acumen in graduate and undergraduate students.

Research Areas

  • Animal Tissue culture
  • Enzyme Technology
  • Production and Purification of high value biomolecules
  • Plant tissue culture
  • Plant Stress Physiology
  • Genomics
  • Transcriptomics
  • Molecular Virology
  • Drug delivery
  • Bio-nanotechnology

Faculty Profile

group-photo

2Dr. Shilpa S. Chapadgaonkar
Head- Molecular Biosciences research cluster
Faculty of Engineering & Technology
Manav Rachna International Institute of Research and Studies (formerly MRIU)
Faridabad, Haryana
INDIA
Mobile No : 9818897755
email id : shilpas.fet@mriu.edu.in
Experience : 9 years
Specialization : Animal tissue culture

Research Interests
My experience has enriched and spurred my interest in the field of bioprocess technology. Bioprocess Technology is essential for translating the discoveries of biotechnology into tangible commercial products, thereby reaping the benefits of biotechnology.

Large scale animal cell culture: There is an immense need of development of efficient processes for the production of biopharmaceuticals. I am working for development of model systems for study of human diseases.

Enzyme Technology: Enzymes are exciting molecules to work with. My research focuses to work on immobilization of enzymes, enzymes from extremophiles, enzymes for activation of prodrugs etc.

New drugs and drug delivery methods: New drugs and new drug delivery systems are required to improve the safety and efficacy of the drugs. Development in new Drug delivery systems would offer the additional benefits of ease of administration, increased patient compliance, decreased side effects and cost reduction.

Tissue engineering: Development in the field of tissue engineering has yielded a novel set of tissue replacement parts & implementation strategies. Research in biomaterials, stem cells, growth factors propelled the growth of tissues in vitro in laboratory from combinations of scaffolds, cells and biologically active molecules. More research is required to achieve the development of functional organs and complex functional body parts by tissue engineering approaches.


Professor Joseph Davis

Ph.D., PGDM., DMLT (CMCH)

Department of Biotechnology

Faculty of Engineering and Technology

ManavRachna International Institute of Research & Studies, Faridabad, Haryana

Mobile: 9891888937

Email: joseph.fet@mriu.edu.in

Publications: 27

Patents: 3

Specialization: R&D of small molecule drugs and biologics, Cell Biology (Specialization – Glycobiology), Animal Cell culture,  Biochemistry, Enzymology, Medical Technology, Infectious Diseases, Immunological Methods

Research interests:Dr. Davis was a trained Biologist and acquired his Ph.D. from Christian Medical College & Hospital, Vellore in Biomedical Faculty. His postdoctoral research was from The Burnham Institute and University of California, San Diego, California. He has studied a rare group of diseases termed Congenital Disorders of Glycosylation (CDG) and the enzyme ATPase kinetic mechanism funded by NIH, Bethesda. Dr. Davis is also an experienced drug discovery professional having more than 14 years Research & Development (R&D) experience in national and multinational pharmaceutical companies like Ranbaxy Laboratories, Daiichi-Sankyo Pharmaceutical (Japan) and Orchid Chemicals &Pharamaceuticals. He is a recipient of many awards such as Winner, Daiichi Sankyo Team of the Year for anti-malaria research, Ranbaxy Team Excellence awards and UGC-CSIR  andGATE Fellowships

The main research interests of Dr. Davis are to continue R&D research in emerging therapeutic domains like diabetes, inflammatory diseases, cancer, infectious diseases and phytomedicine; To set up facility for screening of compounds against battery of assays (both cell-based and cell-free) for consultation and collaboration with Industries and Academia; To set up facility for bioassay-guided fractionation for Phytomedicine research; To set up facility for new or generic enzymes/protein research involving cloning, expression, purification and characterization


1Dr. Pushpa C. Tomar
Associate Professor, Department of Biotechnology
Faculty of Engineering & Technology
Manav Rachna International Institute of Research and Studies (formerly MRIU)
Faridabad, Haryana
INDIA
Mobile No : 9968295295
Email id : pushpa.fet@mriu.edu.in
Experience : 11.5 years
Specialization : Plant Biotechnology & Stress Physiology

Research Interests
The focus of my research is to explore the Cad presence and functions in higher plants, so as to throw some light on future prospects. Areas of specialization include establishing and maintenance of plant cell and tissue cultures, studying different molecular mechanisms underlying abiotic stress and stress induced signaling pathways in plants and how polyamines especially Cad helps in mitigation stress conditions in different plants. Furthermore the PA’s roles are confirmed at the molecular level also. Moreover in recent past PA presence in brain is suggested to be involved in damage repair and cancer prevention. This medical pharmacological aspect needs detail investigation for developing precise, specific aid to ailing people.


3Dr. Soma Patnaik
Assistant Professor, Department of Biotechnology
Faculty of Engineering & Technology
Manav Rachna International Institute of Research and Studies (formerly MRIU)
Faridabad, Haryana
INDIA
Mobile No : 9891308868
Email id : soma.fet@mriu.edu.in
Experience : 4 years
Specialization : Nanobiotechnology, Drug delivery
Publications : 14

Research Interests
Nanoparticles mediated gene delivery has attracted the attention of researchers both in academia and industry.

Nanoparticles owing to their small size easily traverse across the cellular membrane. For enhancing the bioavailability of the entrapped molecules and also to achieve the desired therapeutic response of the molecules, the nanoparticulate size of the matrix is desired. Nanoparticulate systems are attractive methods of delivery owing to the versatility, ease of preparation, and protection conferred to encapsulated gene of interest or drug.

These carrier systems provide protection to the entrapped drug or gene during transit in the systemic circulation. Nanoparticles usually have a high surface area to volume ratio and thus, are able to efficiently encapsulate nucleic acids or drugs efficiently.

These particles can be made to reach a target site by attaching cell-specific ligands, thereby making these vectors reach specific tissues and cells in the body.


4Dr. Kapila Kumar
Assistant Professor, Department of Biotechnology
Faculty of Engineering & Technology
Manav Rachna International Institute of Research and Studies (formerly MRIU)
Faridabad, Haryana
INDIA
Mobile No : 9910303402
Email id : kapila.fet@ mriu.edu.in
Experience : 2.5 years
Specialization : Infectious Diseases,Therapeutics and Functional Genomics

I joined Department of Biotechnology, FET, MRIIRS as an Assistant Professor in 2015. My research areas focus on infectious diseases, Therapeutics and functional Genomics. Before joining MRIIRS, I completed my Ph.D. in 2013 under the guidance of Dr. Sanjay Gupta from JIIT, Noida. I have worked on DBT and DST funded research projects in collaboration with Delhi University with focus on the interaction studies for Chandipura and Chikungunya viruses as is evident from my publications in the area. I have International and national publications in high impact journals. I did my post-graduation in specialized field of Human Genomics from Panjab University, Chandigarh from and graduation in Genetics from Kurukshetra University. I was University second Rank holder both at UG and PG levels. I have qualified National Eligibility (NET) test conducted by CSIR.

My research interests are to better understand the virus-host protein interactions, identify host proteins or pathways required by some emerging and reemerging viruses. Some proteomic approaches with molecular virology, genomic, and bioinformatics based approaches can be combined to achieve these goals. Some high-throughput proteomic technologies for screening and mapping virus-host interactomes and for screening small molecule libraries for inhibitors of protein-protein interactions can be applied in the continuous process of exploring newer antiviral approaches.


5Dr. Rajesh Ghangal
Assistant Professor, Department of Biotechnology
Faculty of Engineering & Technology
Manav Rachna International Institute of Research and Studies (formerly MRIU)
Faridabad, Haryana
INDIA
Mobile No : 09868413661
Email id : rajeshghangal.fet@mriu.edu.in
georgian3063@gmail.com
Experience : 3 years
Specialization : Plant Molecular Biology and Bioinformatics

Research Interests
Next generation sequencing technologies give large amount of data in short span of time. However, assembling and inferring useful information from such a large data is a critical issue. My area of interest is transcriptome sequencing/analysis of medicinally important plants using next generation sequencing technologies and various bioinformatics tools. My aim is to generate useful genomic resources (transcriptome assembly, transcriptome annotation, identification of microsatellites, gene family characterization etc.) for the scientific community for further genetic enhancement.

Abiotic stresses and water-deficit conditions are highly prevailing worldwide, and with the global temperature rising this problem is going to be escalating in coming years. Therefore, my interest also lies in elucidating the molecular mechanism occurring in plants to evade abiotic stress which are growing in such harsh environment in nature itself. Genes have been identified through subtractive hybridization cloning and real time analysis have revealed their role in abiotic stress management. Characterization of such genes and gene families will be a useful resource for the scientific community which can be harnessed for crop improvement by raising transgenic and/or implementing breeding programs.

Areas of specialization include library construction, sequencing and its analysis using bioinformatics tools, and studying different molecular mechanisms underlying abiotic stress in plants.